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About Type 2 Diabetes and High Cholesterol

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Type 2 diabetes

Type 2 diabetes? High cholesterol? Or both? Welchol, along with diet and exercise, is the only FDA-approved medicine with a single active ingredient proven to lower both high blood sugar (A1C) and LDL-C or “bad” cholesterol in adults with type 2 diabetes and high cholesterol.

Learn more about type 2 diabetes and high cholesterol below:

Type 2 Diabetes and Cholesterol

WELCHOL is not for those with blood triglyceride levels of > 500 mg/dL

Type 2 diabetes is the more common form of diabetes1

95% of people with diabetes have type 2 diabetes2,3

More than 90% of people with type 2 diabetes are overweight or obese3

Type 2 diabetes is often associated with obesity, family history, and physical inactivity.3 Common symptoms of diabetes may include urinating often, feeling very thirsty, feeling very hungry (even though you are eating), extreme fatigue, blurry vision, cuts/bruises that are slow to heal, and tingling, pain, or numbness in the hands and/or feet (type 2). However, some people with type 2 diabetes may not experience any symptoms.4

Type 2 diabetes in adults is a chronic condition that should be taken seriously

Type 2 diabetes can be associated with many serious health complications including5:

  • Neuropathy (tingling, pain, numbness, or weakness in the feet and/or hands)
  • Kidney disease
  • Eye complications
  • Skin complications
  • High blood pressure
  • Stroke

Welchol has not been shown to prevent heart disease, heart attacks, stroke, or any of the above risks.

Please see "What is Welchol® (colesevelam HCl)" and "Important Safety Information about Welchol" below.

The American Diabetes Association (ADA) explains that type 2 diabetes is a problem with the body that causes blood sugar levels to be high, either because the body doesn't make enough of the insulin hormone, or the body does not use insulin properly. When your body does not use insulin properly, this is called insulin resistance. At first, the pancreas makes extra insulin to make up for it. But, over time your pancreas isn’t able to keep up and can’t make enough insulin to keep your blood sugar levels normal. Type 2 diabetes is treated with lifestyle changes (healthy eating and exercise), oral medications (pills), and as a last option, insulin.1

A key to managing type 2 diabetes is controlling blood sugar levels

When managing type 2 diabetes, the ADA suggests these goals for most nonpregnant adults with diabetes. However, check with your doctor for the proper diabetes management for you.6-8:

  • An A1C of <7%
  • Blood sugar levels (before meals) of: 80 to 130 mg/dL
  • Blood sugar levels (1 to 2 hours after starting a meal): Less than 180 mg/dL

A1C and blood sugar targets are different for every type 2 diabetes patient and depends on various factors, some of which are:

  • How long the patient has had diabetes
  • Age
  • Other disease states the patient has
  • A condition known as CVD or advanced microvascular complications
  • The occurrence of low blood sugar (hypoglycemia)

One way your healthcare provider measures your blood sugar levels is with a hemoglobin A1C test. It shows your average blood glucose levels over the last 3 months. It is the best way to monitor your overall blood sugar levels during this time and see how well your diabetes treatment plan is working.7,9

Another step toward leading a healthy life with type 2 diabetes is learning some new habits. These include10:

  • Choosing what, how much, and when to eat
  • Getting physically active
  • Checking your blood glucose (if your doctor prescribes it)
  • Going to your doctors' appointments
  • Learning all you can about diabetes
  • Taking medicine as your doctor prescribes it

Remember to talk to your healthcare provider before making any changes to your diet or exercise plan.

WELCHOL is not for those with blood triglyceride levels of > 500 mg/dL

High cholesterol in the body may lead to other serious health problems11

Our bodies use cholesterol to make hormones, Vitamin D, and substances that help us digest foods. It's important to have the right balance of the different types of cholesterol in our bodies.

If there is too much LDL-C or "bad" cholesterol in your arteries, it can be called high cholesterol. If you have too much "bad" cholesterol, it's important to work with your doctor to lower these levels to reach your target goal.

Controlling your level of "bad" cholesterol is important. High levels of "bad" cholesterol may cause heart disease. "Bad" cholesterol builds up on the walls of the blood vessels over time. The blood vessels then become narrow. This may happen to the blood vessels going to the heart and brain. The result may be a heart attack, angina, stroke, or other diseases.

Welchol has not been shown to prevent heart disease, heart attacks, or any other of the above conditions.

Your diet and lifestyle changes may help you manage your cholesterol12

If your "bad" cholesterol levels are too high, diet and lifestyle changes may help you manage your cholesterol and keep it lower. The following may help you promote low cholesterol12:

  • Make sure to stick to a heart-healthy diet
  • Stay physically active
  • Maintain a healthy weight
  • Quit smoking (or don't start)
  • If you have been prescribed cholesterol medicine, take it as prescribed
  • Follow any other recommendations your healthcare provider may have


Remember to talk to your healthcare provider before making any changes to your diet or exercise plan.

Take the Next Step

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Take the Next Step and Save!

Learn more about the Welchol Savings Card.

Not all patients are eligible, see program terms and conditions.


Savings for Welchol are subject to a maximum benefit of $150 for a 30-day prescription and $450 for a 90-day prescription. Other restrictions apply.

*Based on a $24 co-pay for a 90-day supply
†Based on a $25 co-pay for a 30-day supply

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Important Safery Information

What is Welchol® (colesevelam HCI)?

Welchol, along with diet and exercise, lowers LDL or “bad” cholesterol. It can be taken alone or with other cholesterol-lowering medications known as statins.

Welchol lowers LDL cholesterol in boys, and in girls who have had a menstrual period, ages 10 to 17 years, with a condition known as heterozygous familial hypercholesterolemia (a genetic disorder that causes high cholesterol) alone or with other cholesterol-lowering medications known as statins after inadequate control with diet alone.

Welchol, along with diet and exercise, also lowers blood sugar levels in adult patients with type 2 diabetes mellitus when added to other anti-diabetes medications (metformin, sulfonylureas, or insulin).

Welchol should not be used to treat type 1 diabetes or diabetic ketoacidosis.

Welchol has not been studied with all anti-diabetes medications.

Welchol has not been studied in children younger than 10 years old or in girls who have not had a menstrual period.

Important Safety Information About Welchol (colesevelam HCI)

Welchol is available by prescription only. Ask your HCP if Welchol is right for you.

Welchol is not for everyone, especially those with:

  • a history of intestinal blockage,
  • blood triglyceride levels of greater than 500 mg/dL, or
  • a history of pancreatitis (inflammation of the pancreas) due to high triglyceride levels.

Welchol has not been shown to prevent heart disease or heart attacks.

Tell your health care provider (HCP) if you have high triglycerides (greater than 300 mg/dL).

Tell your HCP if you have stomach or intestinal problems, including gastroparesis (when the stomach takes too long to empty its contents), abnormal contractions of the digestive system, a history of major gastrointestinal tract surgery, if you have trouble swallowing, or if you have vitamin A, D, E, or K deficiencies.

Welchol has known interactions with cyclosporine, glimepiride, glipizide, glyburide, levothyroxine, certain birth control pills, olmesartan medoxomil, and metformin extended release (ER). Welchol has not been studied with all combinations of drugs and supplements. Please tell your HCP about all medications and supplements you may be taking before beginning Welchol, as your HCP may tell you to take your other medications and supplements 4 hours before taking Welchol.

Remember to tell your HCP if you are pregnant, plan to become pregnant, or are breastfeeding.

Welchol (colesevelam HCl) for Oral Suspension should not be taken in its dry form.

Welchol for Oral Suspension is recommended for, but not limited to, use in appropriate pediatric patients as well as any patient who has difficulty swallowing.

Phenylketonurics: Welchol for Oral Suspension contains 27 mg phenylalanine per 3.75 gram dose.

In clinical trials, the adverse reactions observed in ≥2% of patients, and more commonly with Welchol than placebo (“sugar pill”), regardless of investigator assessment of causality seen in:

  • Adult patients with high LDL (“bad”) cholesterol were:
    constipation, indigestion, nausea, accidental injury, weakness, sore throat, flu-like symptoms, runny nose, and muscle aches
  • Pediatric patients with high LDL (“bad”) cholesterol were:
    inflamed nasal passages and throat, headache, fatigue, creatine phosphokinase (a muscle enzyme) increase, runny nose, and vomiting
  • Adult patients with Type 2 Diabetes were:
    constipation, low blood sugar (hypoglycemia), indigestion (dyspepsia), nausea, high blood pressure (hypertension), and back pain

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

For patients having difficulty affording their Daiichi Sankyo medication, please call the Daiichi Sankyo Patient Assistance Program at 1-866-268-7327 for more information or visit

Click here for full Product Information about Welchol.

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Type 2 diabetes and high cholesterol

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