While statins work in the liver, Welchol is a treatment that goes to work in your intestines, lowering both your “bad” cholesterol and your high blood sugar (A1C) levels. The way Welchol lowers blood sugar is unknown.

Welchol is not for everyone. Please see Important Safety Information below.


What is Welchol® (colesevelam HCl)?

Welchol, along with diet and exercise, lowers LDL or "bad" cholesterol. It can be taken alone or with other cholesterol-lowering medications known as statins.

Welchol lowers LDL cholesterol in boys, and in girls who have had a menstrual period, ages 10 to 17 years, with a condition known as heterozygous familial hypercholesterolemia (a genetic disorder that causes high cholesterol) alone or with other cholesterol-lowering medications known as statins after inadequate control with diet alone.

Welchol, along with diet and exercise, also lowers blood sugar levels in adult patients with type 2 diabetes mellitus when added to other anti-diabetes medications (metformin, sulfonylureas, or insulin).

Welchol should not be used to treat type 1 diabetes or diabetic ketoacidosis.
Welchol has not been studied with all anti-diabetes medications.
Welchol has not been studied in children younger than 10 years old or in girls who have not had a menstrual period.

Welchol is available by prescription only. Ask your HCP if Welchol is right for you.

Welchol is not for everyone, especially those with:

  • a history of intestinal blockage,
  • blood triglyceride levels of greater than 500 mg/dL, or
  • a history of pancreatitis (inflammation of the pancreas) due to high triglyceride levels.

Welchol has not been shown to prevent heart disease or heart attacks.

Tell your health care provider (HCP) if you have high triglycerides (greater than 300 mg/dL).

Tell your HCP if you have stomach or intestinal problems, including gastroparesis (when the stomach takes too long to empty its contents), abnormal contractions of the digestive system, a history of major gastrointestinal tract surgery, if you have trouble swallowing, or if you have vitamin A, D, E, or K deficiencies.

Welchol has known interactions with cyclosporine, glimepiride, glipizide, glyburide, levothyroxine, certain birth control pills, olmesartan medoxomil, and metformin extended release (ER). Welchol has not been studied with all combinations of drugs and supplements. Please tell your HCP about all medications and supplements you may be taking before beginning Welchol, as your HCP may tell you to take your other medications and supplements 4 hours before taking Welchol.

Remember to tell your HCP if you are pregnant, plan to become pregnant, or are breastfeeding.

Welchol (colesevelam HCl) for Oral Suspension should not be taken in its dry form.

Welchol for Oral Suspension is recommended for, but not limited to, use in appropriate pediatric patients as well as any patient who has difficulty swallowing.

Phenylketonurics: Welchol for Oral Suspension contains 27 mg phenylalanine per 3.75 gram dose.

In clinical trials, the adverse reactions observed in ≥2% of patients, and more commonly with Welchol than placebo ("sugar pill"), regardless of investigator assessment of causality seen in:

  • Adult patients with high LDL ("bad") cholesterol were:
    constipation, indigestion, nausea, accidental injury, weakness, sore throat , flu-like symptoms, runny nose, and muscle aches
  • Pediatric patients with high LDL ("bad") cholesterol were:
    inflamed nasal passages and throat, headache, fatigue, creatine phosphokinase (a muscle enzyme) increase, runny nose, and vomiting
  • Adult patients with Type 2 Diabetes were:
    constipation, low blood sugar (hypoglycemia), indigestion (dyspepsia), nausea, high blood pressure (hypertension), and back pain

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

For patients having difficulty affording their Daiichi Sankyo medication, please call the Daiichi Sankyo Patient Assistance Program at 1-866-268-7327 for more information or visit www.dsi.com/news/patientassistance.html.

Click here for Full Product Information for Welchol.

Welchol® (colesevelam HCl) lowers "bad" cholesterol differently from statins. While statins work in your liver, Welchol works in your intestines. It's a "bile acid sequestrant." Bile acids are needed to help digest fat from the foods we eat. Welchol attaches to bile acids and removes some of them from the body. When levels are reduced, your liver needs to make more. Your liver takes cholesterol from the bloodstream to do so—lowering your "bad" cholesterol.

Welchol also lowers your A1C. It's not known exactly how it does this, but studies have shown that, when added to metformin, sulfonylurea, or insulin therapy, Welchol helped significantly lower A1C levels in adults with type 2 diabetes. Welchol may increase blood levels of metformin when taking in combination with metformin extended release (ER). Check with your doctor about monitoring your blood sugar levels.

Welchol is not for everyone, especially those with intestinal blockage, those with blood triglyceride levels of greater than 500 mg/dL, or those with a history of pancreatitis (inflammation of the pancreas) due to high triglyceride levels. Ask your doctor if Welchol is right for you.

Please see Important Safety Information about Welchol below.

Ask your healthcare professional to check your lipid levels, including trigylceride and non-HDL cholesterol levels, before starting Welchol and periodically thereafter.

When to expect results

Your treatment milestones with Welchol
With Welchol, you may start seeing some results in as little as 2 weeks. Stay on Welchol to see continued clinical benefits. Keep moving forward with Welchol.
 

Welchol® Treatment Timeline Welchol® Treatment Timeline​ ​
Learn more about Welchol for “bad” cholesterol and for lowering high blood sugar

Welchol is not right for everyone. Ask your healthcare professional if Welchol is right for you.

Please see Important Safety Information about Welchol below.
TELL ME MORE
Image_Alt_Text.getData() Image_Alt_Text.getData()

Take the Next Step and Save!

Sign up to be a member of the ADDvantage ProgramTM and learn more about the Welchol Savings Card.

START SAVING

Not all patients are eligible, see program terms and conditions.

Savings for Welchol are subject to a maximum benefit of $70 for a 30-day prescription and $125 for a 90-day prescription. Other restrictions apply.

*Based on a $24 co-pay for a 90-day supply
†Based on a $25 co-pay for a 30-day supply