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Efficacy of Welchol in Primary Hyperlipidemia
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Significant LDL-C Reductions
In patients with primary hyperlipidemia, make Welchol the preferred partner to a statin for significant LDL-C reductions in your patients. Welchol increased efficacy without increasing the statin dose.
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Welchol + simvastatin
Welchol added to simvastatin can help your patients achieve significant LDL-C and HDL-C improvements*1,2
In this clinical trial, the most common adverse reactions observed by ≥5% of the subjects after receiving Welchol were flatulence and constipation.
Knapp HH, et al. Am J Med. 2001
Welchol + atorvastatin
Comparable LDL-C reductions between atorvastatin 80 mg and atorvastatin 10 mg + Welchol 3.8g*,1,3
In this clinical trial, the most common adverse reactions observed by ≥5% of the subjects after receiving Welchol were flatulence and constipation.
Hunninghake D, et al. Atherosclerosis. 2001
Welchol: an alternative to statin titration
Adding Welchol can give your patients an alternative to statin titration1,4
Study Designs
Study Design B (Knapp HH, Am J Med. 2001)
Results from a 6-week, multicenter, randomized, double-blind, placebo-controlled study of 258 randomized patients with moderate hypercholesterolemia* (LDL-C ≥160 mg/dL;
TG ≤300 mg/dL) who were not on lipid-lowering medication. Patients were randomized to 1 of the following treatment regimens: placebo, Welchol 3.8 g/day, simvastatin 10 mg/day, Welchol 3.8 g/day + simvastatin 10 mg/day, Welchol 2.3 g/day, simvastatin 20 mg/day, or Welchol 2.3 g/day + simvastatin 20 mg/day.1,2
Study Design C (Hunninghake D, Atherosclerosis. 2001)
Results from a randomized, double-blind, placebo-controlled, 4-week study of 94 randomized patients with moderate hypercholesterolemia* (LDL-C ≥160 mg/dL, TG ≤300 mg/dL) and
LDL-C levels ranging from 156-236 mg/dL. Patients were assigned to 1 of 5 treatment groups: placebo, Welchol 3.8 g/day, atorvastatin 10 mg/day, atorvastatin 80 mg/day, or atorvastatin 10 mg/day + Welchol 3.8 g/day.1,3
*Hypercholesterolemia is now referred to as primary hyperlipidemia
